Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Oxidative stress in LMs fails to trigger an antioxidant response in obesity-induced insulin resistance.
  • Fig. S2. NRF2 is a target of miR-144 in obesity-associated LMs.
  • Fig. S3. Silencing miR-144 in LMs reduces ROS release and leads to decreased expression of miR-144 in hepatocytes.
  • Fig. S4. Silencing miR-144 in LMs reduces oxidative stress and improves hepatic metabolism in insulin resistance.
  • Fig. S5. Proposed model of oxidative stress regulation by LMs in obesity.
  • References (5468)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Supplementary tables S1 to S9:
  • Table S1. GO biological processes (BP) enriched in genes differentially expressed between 9-week-old ob/ob and wt mice based on RNA-seq.
  • Table S2. GO biological processes (BP) enriched in genes differentially expressed between 14-week-old ob/ob and wt mice based on RNA-seq.
  • Table S3. Over-represented pathways between 9-week-old ob/ob and wt mice based on RNA-seq.
  • Table S4. Over-represented pathways between 14-week-old ob/ob and wt mice based on RNA-seq.
  • Table S5. Enriched GO biological processes (BP) between HFD and ND mice based on GRO-seq.
  • Table S6. Enriched GO biological processes (BP) between HFD- and ND-fed mice based on RNA-seq.
  • Table S7. Differentially expressed genes in HFD versus ND mice (GRO-seq) enriched in inflammatory response GO biological process (GO:0006954).
  • Table S8. Differentially expressed genes in HFD versus ND mice (RNA-seq) enriched in inflammatory response GO biological process (GO:0006954).
  • Table S9. Differential expression status of selected NRF2 target genes in 9-week-old ob/ob and wt mice.
  • Data file S2 (Microsoft Excel format). Raw data from figures.