Supplementary Materials

The PDF file includes:

  • Fig. S1. FLNA expression is increased in cortices of patients with FCDII.
  • Fig. S2. FLNA expression is increased in cytomegalic cortical neurons of patients with FCDII.
  • Fig. S3. Original immunoblots for FLNA in human FCDII samples.
  • Fig. S4. The quantity of FLNA is not correlated to the type of FCDII or age of seizure onset or epilepsy duration.
  • Fig. S5. Knocking down FLNA does not affect the degree of S6 phosphorylation.
  • Fig. S6. Delineation of layer 2/3 and layer 5 neurons using ER81 immunostaining.
  • Fig. S7. Single-cell labeling for dendrite (Sholl) analysis.
  • Fig. S8. Original immunoblots.
  • Table S1. Information for patients with FCDII.
  • Table S2. Information for control patients.
  • Table S3. Summary of statistical tests.
  • Table S4. Plasmids.
  • Table S5. Primary and secondary antibodies.
  • Legend for movie S1
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). A Racine grade 4 to 5 seizure in a RhebCA-expressing mouse.
  • Data file S1. Individual-level data for Figs. 1 to 6 and figs. S1, S4, and S5 (provided as separate Excel file).