Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Enrollment flow chart for the study population.
  • Fig. S2. CSF-LDH is not associated with age, gender, and total bilirubin.
  • Fig. S3. Biophysical and pharmacological properties of IASICs in MVN neurons.
  • Fig. S4. Direct cross-talk between bilirubin and ASICs.
  • Fig. S5. Enhanced membrane depolarization, spike firings by bilirubin-dependent increase in currents mediated by ASICs.
  • Fig. S6. Potentiated IASICs by bilirubin had different sensitivities to various inhibitors of ASIC channels in MVN neurons.
  • Fig. S7. Bilirubin and acid induce cell death in brain slices and CHO cells.
  • Fig. S8. Exacerbated brain injury in neonatal mice in vivo conditioned by hyperbilirubinemia and intermittent hypoxia-induced acidosis.
  • Table S1. Detail information for infants with acidosis or hyperbilirubinemia.
  • Table S2. Free bilirubin concentration in CSF of neonates with hyperbilirubinemia (14 subjects) by using a fluorescent protein (UnaG)–based detection method.
  • References (6773)

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