Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Intrathecal pretreatment of BIBN 4096 prevents hindpaw allodynia induced by intrathecal injection of CGRP in naïve female mice.
  • Fig. S2. The PRL/PRLR system is not critical for the development of trauma-induced neuropathic pain in female mice.
  • Fig. S3. Subcutaneous implantation of a single morphine pellet induces hindpaw and periorbital allodynia in female and male mice.
  • Fig. S4. Alteration in the PRL/PRLR system in female and male mice with daily injections of morphine.
  • Fig. S5. Schematic of circulating PRL/PRLR system mediating nociceptor sensitization and OIH in females.
  • Table S1. Binding affinity of (−)- and (+)-oxymorphone.
  • Legend for data file S1
  • References (6674)

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Other Supplementary Material for this manuscript includes the following: