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The PDF file includes:

  • Materials and Methods
  • Fig. S1. Insoluble total αSyn correlates with end-stage paralysis in A53T mice.
  • Fig. S2. Immunoblot analysis of total and pSyn in A53T mice.
  • Fig. S3. pSyn pathology A53T mice localizes to neurons.
  • Fig. S4. Microglial reactivity in A53T mice with pSyn pathology.
  • Fig. S5. pSyn pathology in the cortex in A53T mice.
  • Fig. S6. Sample variance of inflammatory gene expression correlates with pSyn pathology in A53T mice.
  • Fig. S7. Gene expression modules correlate with end-stage paralysis in A53T mice.
  • Fig. S8. Minimal colocalization of pSyn pathology and oligodendrocytes in A53T mice.
  • Fig. S9. pSyn pathology in the striatum after αSyn PFF injection.
  • Table S7. Linear regression analysis of MMSE scores in dbGaP participants.
  • Legends for tables S1 to S6
  • Legend for data file S1
  • Reference (75)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). pSyn IHC differential expression data.
  • Table S2 (Microsoft Excel format). EKO versus E2 differential expression data.
  • Table S3 (Microsoft Excel format). E4 versus E2 differential expression data.
  • Table S4 (Microsoft Excel format). Gene module membership.
  • Table S5 (Microsoft Excel format). Gene-trait significance.
  • Table S6 (Microsoft Excel format). GO analysis for selected modules.
  • Data file S1 (Microsoft Excel format). Primary data.