Supplementary Materials

The PDF file includes:

  • Fig. S1. Widespread expression of human α-synuclein protein in the brain of αSyn-APOE mice.
  • Fig. S2. Widespread expression of GFP in the brain of Ctrl-APOE mice.
  • Fig. S3. Expression of human and mouse α-synuclein in the brain of Ctrl-APOE and αSyn-APOE mice.
  • Fig. S4. α-Synuclein pathology in the substantia nigra region of αSyn-APOE4 mice.
  • Fig. S5. Increased phosphorylated α-synuclein in αSyn-APOE4 mice.
  • Fig. S6. Solubility of human α-synuclein in the brain of Ctrl-APOE and αSyn-APOE mice.
  • Fig. S7. Solubility of total α-synuclein in the brain of Ctrl-APOE and αSyn-APOE mice.
  • Fig. S8. Behavioral abnormalities in αSyn-APOE mice.
  • Fig. S9. Correlation of behavioral performances and α-synuclein pathologies in αSyn-APOE mice.
  • Fig. S10. Correlation of neurodegeneration and astrogliosis with α-synuclein pathologies in αSyn-APOE mice.
  • Fig. S11. Microglial marker expression in αSyn-APOE mice.
  • Fig. S12. DEGs and related pathways between Ctrl-APOE and αSyn-APOE mice in different APOE genetic backgrounds identified by transcriptomic profiling.
  • Fig. S13. Pathways specifically affected in APOE4-TR mice upon human α-synuclein expression.
  • Fig. S14. Glia marker expression in human LBD brain.
  • Table S1. Patient characteristics for LBD cohort.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data for all the figures where n < 20.