Supplementary Materials

The PDF file includes:

  • Fig. S1. Pregating of cell types for tSNE.
  • Fig. S2. Gating hierarchy panel 1.
  • Fig. S3. Gating hierarchy panel 2.
  • Fig. S4. Representative flow plots panel 1.
  • Fig. S5. Representative flow plots panel 2.
  • Fig. S6. No vaccine-induced changes are detectable 1 month after vaccination.
  • Fig. S7. Strong correlations observed within related cell types.
  • Fig. S8. Cell subset frequency correlations between baseline and B3 time points.
  • Fig. S9. Cell subset frequency correlations between baseline and B32 time points.
  • Fig. S10. Anti-CSP and anti-HBV.S IgG titers before and after vaccination in infants and children from Mozambique.
  • Fig. S11. Distribution of participant age along the diffusion-pseudotime trajectory.
  • Fig. S12. Anti-CSP and anti-HBV.S IgG titers before and after vaccination in children from Tanzania and Mozambique.
  • Fig. S13. Dose-dependent toxicity of ciclopirox olamine on B cells in culture.
  • Fig. S14. Highly reproducible flow cytometry data between experiments.
  • Table S1. Participant characteristics.
  • Table S2. Consolidated Standards of Reporting Trials table.
  • Table S3. Antibody panels.
  • Table S4. Manually gated cell subset definitions panel 1.
  • Table S5. Manually gated cell subset definitions panel 2.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (.csv format). Differentially expressed genes between B0 and B32.
  • Data file S2 (.csv format). Differentially expressed genes between anemic and nonanemic children.
  • Data file S3 (Microsoft Excel format). Plasmablast differentiation assay raw data.