Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Mmp9−/− and myeloid-specific Mmp14 conditional knockout mice display normal osteoclast activity in vitro and in vivo.
  • Fig. S2. Characterization of Mmp9/Mmp14 DKO osteoclast precursors.
  • Fig. S3. Mmp9/Mmp14 DKO osteoclasts display normal osteoclastogenesis, gene expression, and intracellular acidification.
  • Fig. S4. Temporal requirements for Mmp9 and Mmp14 in supporting osteoclast function.
  • Fig. S5. Osteoclast Mmp9/Mmp14 activities codetermine bone type I collagenolysis.
  • Fig. S6. Col1ar/r mutant mice exhibit an osteopetrotic phenotype in vivo.
  • Fig. S7. Mmp9/Mmp14 DKO mice exhibit increased bone mass in lumbar vertebrae and display improved biomechanical properties.
  • Table S1. Genotyping PCR primers.
  • Table S2. Quantitative real-time PCR primers.
  • Legends for data files S1 and S2
  • References (8289)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.
  • Data file S2 (.pdf format). Western blotting films.