Supplementary Materials

The PDF file includes:

  • Fig. S1. Differential gene expression (DESeq2) across species.
  • Fig. S2. Serping1 regulates inflammation but not Mtb control in mice.
  • Fig. S3. T cell cytokine profile and myeloid cell recruitment in Mtb-infected Tap1−/− mice.
  • Fig. S4. Protection from Mtb HN878 infection is mediated by Batf2.
  • Fig. S5. IL-17–producing CD4+ TH17 cell cytokines are increased in Mtb-infected Batf2/3−/− mice.
  • Fig. S6. T cell cytokine profile in Mtb-infected Fcgr1−/− mice.
  • Fig. S7. SCARF1 expression drives inflammation within TB granulomas.
  • Fig. S8. Hierarchical gating strategy used to identify myeloid populations in mice lungs.
  • Legends for tables S1 to S6

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). RNA-seq sample metadata and accessions.
  • Table S2 (Microsoft Excel format). FPKM gene expression values and differential expression statistics for the top 1000 mouse genes, including information about ortholog matches in human and macaque.
  • Table S3 (Microsoft Excel format). Significance testing for overlaps of differentially expressed genes between species.
  • Table S4 (Microsoft Excel format). Correlation analysis between ACS signature genes and TB metadata (lung inflammation and bacterial bacteria) among mouse and macaque controller and progressor samples.
  • Table S5 (Microsoft Excel format). Flow cytometry quantification of lung cellular subsets in control and gene-deficient models infected with Mtb.
  • Table S6 (Microsoft Excel format). Significantly enriched Reactome pathways among gene sets of interest.
  • Data file S1 (Microsoft Excel format). Primary data.