Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Chromosome 1q is amplified in a subset of human lung cancer cell lines.
  • Fig. S2. High expression of Golgi-related genes enhances the metastatic properties of 1q-amplified lung cancer cells.
  • Fig. S3. 1q-amplified cancers are PI4KIIIβ dependent.
  • Fig. S4. PI4KB functions cooperatively with coamplified genes on chromosome 1q.
  • Fig. S5. IN-9 induces apoptosis in 1q-amplified, but not 1q-diploid, lung cancer cells.
  • Fig. S6. Selective PI4KIIIβ antagonists have activity against 1q-amplified lung cancer cells.
  • Fig. S7. PI4KIIIβ-dependent PI4P synthesis drives prometastatic properties of 1q-amplified lung cancer cells.
  • Fig. S8. GOLPH3 mediates prometastatic effects of PI4KIIIβ in 1q-amplified cancer cells.
  • Fig. S9. GOLPH3 mediates PI4KIIIβ-driven secretion.
  • Fig. S10. 1q amplification is associated with increased secretion.
  • Fig. S11. PLOD3 maintains H2122 cell survival by activating MMP9.
  • Fig. S12. PI4KIIIβ-dependent secretion regulates processes in the tumor microenvironment.
  • Table S1. Clinical pathological characteristics of lung adenocarcinomas.
  • Table S2. Liquid chromatography–mass spectrometry of conditioned medium samples.
  • Table S3. Primers.
  • Data file S1.
  • References (6979)

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