Supplementary Materials

The PDF file includes:

  • Fig. S1. Engrafted donor mutations in recipients.
  • Fig. S2. Clonal expansion of mutations reaching the threshold for CHIP (≥0.02 VAF) in three patients after HSCT.
  • Fig. S3. Types of somatic substitutions in recipients after HSCT.
  • Fig. S4. The sequencing depth of each ECS library at all time points.
  • Fig. S5. New mutations detected in recipients after HSCT.
  • Fig. S6. ECS calls validated by ddPCR.
  • Fig. S7. Number of detected mutations in genes according to gene length.
  • Fig. S8. Leukemia-free survival of recipients with or without persistent engraftment of donor-derived mutations.
  • Fig. S9. Cumulative incidence of chronic GvHD in recipients with or without persistent engraftment of donor-derived mutations.
  • Legends for data files S1 to S6

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Detected somatic mutations in donors.
  • Data file S2 (Microsoft Excel format). Detected somatic mutations in recipients after HSCT after removing recipient’s own hematopoietic clones.
  • Data file S3 (Microsoft Excel format). Shared variants in pre-HSCT and post-HSCT recipient samples due to incomplete clearance of recipient’s hematopoietic clones after HSCT.
  • Data file S4 (Microsoft Excel format). Analysis of recipient clinical outcomes in relation to engraftment of donor-derived mutations.
  • Data file S5 (Microsoft Excel format). Recurrently mutated genes in adult and pediatric AML.
  • Data file S6 (Microsoft Excel format). ddPCR probe sequences.