Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Validation of leptin-overexpressing ES cells and leptin-overexpressing mice.
  • Fig. S2. Bioactivity of leptin.
  • Fig. S3. Circulating leptin concentrations during postnatal dox exposure.
  • Fig. S4. Dox-induced chronic hyperleptinemia (P63 to P203) in adult mice with concurrent HFD feeding.
  • Fig. S5. Release of adult mice from dox-induced chronic (P63 to P203) hyperleptinemia and HFD feeding.
  • Fig. S6. Energy expenditure assessment (indirect calorimetry) at 26 weeks of age in postnatally (P0 to P22) hyperleptinemic female mice after 16 weeks of HFD feeding.
  • Legends for data files S1 and S2
  • Reference (74)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Primary data file used to generate main figures.
  • Data file S2 (Microsoft Excel format). Primary data file used to generate supplementary figures.