Supplementary Materials

The PDF file includes:

  • Fig. S1. Image processing pipeline related to the voxelwise spatial correlation analyses presented in Fig. 3.
  • Fig. S2. Image processing pipeline related to the ROI analyses shown in Figs. 4 and 5.
  • Fig. S3. LMEMs using FreeSurfer-defined cortical ROIs and non-PVC SUVR data (related to Fig. 4 and table S2).
  • Fig. S4. Associations between neuroimaging measures and clinical decline.
  • Fig. S5. Association between patient’s age and global neuroimaging measures (related to Fig. 6).
  • Fig. S6. Summary of bivariate associations and mediation models between global cortical neuroimaging measures at baseline, global cortical longitudinal atrophy, and age (related to Fig. 6).
  • Fig. S7. Voxelwise associations between patient’s age, baseline FTP-PET, and longitudinal atrophy (related to Fig. 6).
  • Fig. S8. Analyses of the influence of atypical AD phenotypes on the main results.
  • Fig. S9. Analyses of the influence of MRI scanner switch on the main results.
  • Table S1. Details of linear regression models presented in Fig. 2.
  • Table S2. Details of LMEMs shown in Fig. 4.
  • Legend for data file S1

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Data used for the analyses presented in the manuscript.