Supplementary Materials

The PDF file includes:

  • Fig. S1. ZIKV challenge of nonpregnant vaccinated animals.
  • Fig. S2. Correlation of neutralizing antibodies on the day of ZIKV challenge with magnitude of viremia.
  • Fig. S3. Kinetics of whole-virion IgG binding antibodies and associations with viremia in pregnant macaques.
  • Fig. S4. Fetal growth in rhesus macaque dams in ZIKV DNA vaccine or control groups, monitored via US and CT scans.
  • Fig. S5. Fetal measurements collected at euthanasia from ZIKV vaccine, control, and historical control animals.
  • Fig. S6. Detection of ZIKV RNA in amniotic fluid.
  • Fig. S7. ZIKV RNA in fetal macaques from control pregnancies (extended testing).
  • Fig. S8. Presence of ZIKV vRNA in the adult female macaques at time of euthanasia.
  • Fig. S9. Placental pathology.
  • Fig. S10. Ependymal cell loss in fetal brains.
  • Fig. S11. Fetal brain lesions.
  • Fig. S12. Cytokines and chemokines in amniotic fluid from vaccinated animals are not different from controls.
  • Table S1. Summary of animal biodata.
  • Table S2. Summary of fetal pathology.
  • Table S3. Fetal pathology scoring system.
  • Table S4. Summary of late pregnancy complications in three vaccinated animals.
  • Table S5. Summary of pathological findings in adult female macaques.

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Other Supplementary Material for this manuscript includes the following: