Supplementary Materials

The PDF file includes:

• Fig. S1. Characterization of Msut2 KO mice.
• Fig. S2. Msut2 KO decreases accumulation of pathological tau.
• Fig. S3. Msut2 KO mice have normal cognitive and locomotor abilities.
• Fig. S4. MSUT2, PABPN1, and poly(A) mRNA colocalize in nuclear speckles.
• Fig. S5. MSUT2 and PABPN1 have opposing effects on tau aggregation.
• Fig. S6. MSUT2 overexpression in mouse hippocampus using AAV-Msut2.
• Fig. S7. Effect of MSUT2 overexpression on astrocytes in the mouse hippocampus.
• Fig. S8. Msut2 deletion suppresses reactive microgliosis in PS19 mice.
• Fig. S9. Msut2 deletion does not protect against astrocytosis induced by kainic acid.
• Fig. S10. Schematic showing the potential molecular mechanism of MSUT2 activity.
• Legends for tables S1 to S4

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Msut2 KO versus C57BL/6 RNA-seq gene expression changes.
• Table S2 (Microsoft Excel format). Msut2 KO versus C57BL/6 RNA-seq exon inclusion changes.
• Table S3 (Microsoft Excel format). Msut2 KO versus C57BL/6 RNA-seq poly(A) site selection.
• Table S4 (Microsoft Excel format). Characteristics of human AD cases.
• Data file S1 (Microsoft Excel format). Source data for Figs. 1D, 4, A to D, and 5, D to I.