Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. CXCR2 is a surface marker for NE cells at all stages of PCa evolution.
  • Fig. S2. CXCR2+ NE cells from human primary PCa show distinct gene expression signatures from CXCR2 luminal cell subpopulation.
  • Fig. S3. CXCR2 drives NE phenotype and therapeutic resistance.
  • Fig. S4. CXCR2 drives the NE secretion of proangiogenic factors and contributes to premetastatic niche formation.
  • Fig. S5. CXCR2 inhibitor inhibits CRPC growth in preclinical model.
  • Table S1. Gene set enriched in CXCR2+ NE cells.
  • Table S2. Gene set enriched in CXCR2 luminal cells.
  • Table S3. Oncogenic gene set enrichment in CXCR2 NE (CXCR2+ malignant versus basal benign).
  • Table S4. Six hundred eighty-two–gene signature in CXCR2 NE cells.
  • Table S5. Primers for qRT-PCR.
  • Table S6. Targeting sequences for CXCR2 sgRNA.
  • References (3133)

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Other Supplementary Material for this manuscript includes the following: