Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Chemical structure of PF-06427878.
  • Fig. S2. Effect of PF-06427878 on circulating hepatic biomarkers in Wistar Han IGS rats and cynomolgus monkeys in 2-week toxicology studies.
  • Fig. S3. Subject disposition in clinical studies of PF-06427878 in healthy humans.
  • Fig. S4. Descriptive summary (n, means, and SEM) and individual participant–level MRI-PDFF data for liver fat in humans (study B7871005).
  • Table S1. Effect of PF-06427878 on selected clinical chemistry parameters in the STAM mouse model of NASH.
  • Table S2. Effect of PF-06427878 on fasting serum lipids on day 14 in studies B7871002 and B7871005.
  • Legend for Data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data from nonclinical in vivo studies.