Supplementary Materials

The PDF file includes:

  • Fig. S1. Top 100 up-regulated genes in CL lesions relative to healthy skin.
  • Fig. S2. Age, sex, lesion size, and delayed-type hypersensitivity response are not associated with treatment failure.
  • Fig. S3. CombiROC analysis identifies gene combinations for accurately predicting treatment outcome.
  • Fig. S4. Absolute quantification of L. braziliensis parasites in CL lesions by qPCR.
  • Fig. S5. Relative abundance of parasite transcripts correlates with expression of eight ViTALs.
  • Fig. S6. Non-ViTAL genes do not correlate with parasite load.
  • Fig. S7. Coverage plot for L. braziliensis read mapping.
  • Fig. S8. Model showing proposed role of parasite load in determining treatment outcome in CL.
  • Table S1. Demographic and clinical metadata from patients with CL.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). GO enrichment analysis results for 250 ViTALs.
  • Data file S2 (.pdf file). Supplementary code file.