Supplementary Materials

The PDF file includes:

  • Fig. S1. Skewed Igκ repertoire in patients with RA and decreased ATM function.
  • Fig. S2. Group I and group II patients with RA display similar biometric characteristics.
  • Fig. S3. Decreased pATM induction in T cells from patients with RA.
  • Fig. S4. Decreased pATM induction in non–T and non–B cells from patients with RA.
  • Fig. S5. In vitro inhibition of ATM activation in human B cells.
  • Fig. S6. Reconstitution of human lymphocytes in NSG humanized mice.
  • Fig. S7. B cell precursors are the major human CD45+ cell population in the bone marrow of NSG humanized mice.
  • Fig. S8. Trabecular thickness and ratios of bone volume to tissue volume in NSG humanized mice injected or not with ATMi.
  • Table S1. Igκ repertoire of antibodies expressed by new emigrant/transitional B cells from patients with RA*, patients with AT, and HDs*.
  • Table S2. Additional characteristics of group I and group II patients with RA.
  • Table S3. Igκ repertoire of antibodies expressed by new emigrant/transitional B cells from NSG humanized mice.

[Download PDF]

Other Supplementary Material for this manuscript includes the following: