Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Morphology and functionality of a species-specific dual-cell Liver-Chip.
  • Fig. S2. Cytochrome P450 enzyme activity in a species-specific dual-cell Liver-Chip.
  • Fig. S3. Comparison of hepatic functionalities between a dual- and quadruple-cell Liver-Chip.
  • Fig. S4. Detection of glucuronide metabolites of APAP and hepatocellular injury using a quadruple-cell human Liver-Chip.
  • Fig. S5. JNJ compound structures.
  • Fig. S6. Transaminase data from JNJ-1 treatment in human phase 1 clinical trial and rat and dog in vivo studies.
  • Fig. S7. Stellate cell activation after TAK-875 treatment.

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