Supplementary Materials

The PDF file includes:

  • Fig. S1. Hypercholesterolemia promotes platelet-myeloid interactions.
  • Fig. S2. Platelets and plasma total cholesterol and triglyceride profile.
  • Fig. S3. Monocyte adhesion.
  • Fig. S4. Plaque proliferation quantification.
  • Fig. S5. Plaque apoptosis quantification.
  • Fig. S6. Silencing of Socs3 and macrophage phenotype.
  • Fig. S7. Macrophage Stat1 and Stat3 expression.
  • Fig. S8. scRNA-seq macrophage Socs1 and Socs3 expression.
  • Fig. S9. Macrophage Socs3 mRNA expression after treatment with IL-6.
  • Fig. S10. Inhibition of IL-6 signaling with α-gp130 overcomes platelet-mediated macrophage efferocytosis defects.
  • Fig. S11. SOCS1:SOCS3 is inversely associated with PF4 and IL1B in women with myocardial infarction, and correlation between MPA and atherosclerosis severity.
  • Fig. S12. MPA is associated with PAD severity.
  • Fig. S13. Association between aspirin and clopidogrel therapy and MPA.
  • Table S1. Demographics of individuals with lower extremity atherosclerosis.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data from figures.