Supplementary Materials

The PDF file includes:

• Fig. S1. Wake and sleep questionnaires for FNSS.
• Fig. S2. Generation of Npsr1-Y206H mice.
• Fig. S3. Sleep/wake measurements in Npsr1-Y206H and Npsr1 KO mice.
• Fig. S4. EEG data analysis of sleep/wake behavior in Npsr1-Y206H mice.
• Fig. S5. High sleep pressure was observed in Npsr1-Y206H mice.
• Fig. S6. Hyperphosphorylated SNIPPs were observed in Npsr1-Y206H mice after SD.
• Fig. S7. Calcium imaging of LH neurons shows increased activity for one subtype in Npsr1-Y206H mice.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Raw data.