Supplementary Materials

The PDF file includes:

• Fig. S1. Explant culture permitted the isolation of substantial numbers of human tissue-resident lymphocytes.
• Fig. S2. Vδ1⁺ T cells display innate-like responsiveness.
• Fig. S3. αβ and γδ T cells could be isolated from breast tumors and phenotypically resemble those from healthy tissue.
• Fig. S4. Both αβ and γδ T cells are enriched in tumors compared with paired nonmalignant tissue.
• Fig. S5. Vδ1⁺ T cells show no evidence of tumoral clonal focusing in contrast to αβ T cells.
• Fig. S6. There is limited Vδ1 repertoire overlap between tumor and paired nonmalignant tissue within patients.
• Table S1. Lymphocyte subtypes observed ex vivo after enzymatic digestion and in grid explant cultures.
• Table S2. Clinical features of KCL TNBC cohort.
• Table S3. Clonality metrics of down-sampled TCRs.
• Table S4. Clonality metrics of raw TCRs.
• Table S5. Public intratumoral phospho-antigen reactive Vδ2 CDR3 sequences and samples in which they were shared.
• Table S6. Antibodies and key reagents table.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Primary data.