Supplementary Materials

This PDF file includes:

• Fig. S1. Safety and efficacy profile of CRMP-treated, high-fat, fructose-fed cynomolgus macaques.
• Fig. S2. Oral CRMP dose escalation study in dysmetabolic rhesus macaques.
• Fig. S3. Plasma DNP concentrations in dysmetabolic rhesus macaques.
• Fig. S4. CRMP treatment does not alter oxidative stress in dysmetabolic rhesus macaques.
• Fig. S5. CRMP treatment does not alter whole-body glucose tolerance in dysmetabolic rhesus macaques.
• Fig. S6. Hepatic mitochondrial fluxes in dysmetabolic rhesus macaques treated with CRMP.

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