Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Growth kinetics of MeV-NP and MeV-Z in Vero NK cells.
  • Fig. S2. Monitoring of body temperature in animals after immunization.
  • Fig. S3. Transcriptomic changes after immunization.
  • Fig. S4. Cellular pathway changes after immunization determined using the “Hallmark” gene set.
  • Fig. S5. Cellular pathway changes after immunization determined using the Kyoto encyclopedia of genes and genomes (KEGG) gene set.
  • Fig. S6. Cellular pathway changes after immunization determined using the “Reactome” gene set.
  • Fig. S7. Proteomic changes after immunization.
  • Fig. S8. Principal components analyses of the proteomic changes after immunization.
  • Fig. S9. Dynamics of white blood cell counts after challenge with LASV.
  • Fig. S10. Blood biochemistry of LASV-challenged animals.
  • Fig. S11. Viral RNA load in monkeys after LASV challenge.
  • Fig. S12. Memory T cell differentiation after LASV challenge.
  • Fig. S13. Specific T cell responses against Z protein peptides after LASV challenge.
  • Table S1. Genetic stability of the LASV genes introduced in measles-based vaccines.
  • Table S2. Detection of vaccine RNA by RT-PCR.
  • Table S3. Humoral responses after immunization.

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Other Supplementary Material for this manuscript includes the following: