Supplementary Materials

The PDF file includes:

  • Fig. S1. Subregions evaluated in the ovine medial tibial plateau.
  • Fig. S2. Correlation between the location of osteophytes and OA lesions in sheep.
  • Fig. S3. Histopathological scores of the ovine articular cartilage.
  • Fig. S4. OA patterns of ovine articular cartilage and subchondral bone plate thickness.
  • Fig. S5. Topographical patterns of the OA changes of the ovine subchondral bone plate.
  • Fig. S6. Topographical patterns of the OA changes of the ovine subarticular spongiosa.
  • Fig. S7. Cluster analysis of the ovine articular cartilage and the subchondral bone parameters at 6 weeks after pMMx.
  • Fig. S8. Cluster analysis of the ovine articular cartilage and the subchondral bone parameters at 6 months after pMMx.
  • Fig. S9. Minimally required ovine subchondral bone parameters to clearly separate normal from pMMx with multivariate analysis at 6 months.
  • Fig. S10. Human early OA meniscus and cartilage scores.
  • Fig. S11. Additional structural parameters of subarticular spongiosa in human late OA.
  • Fig. S12. Proposed schematic of the initiation and spatiotemporal progression of OA by a defined meniscal tissue loss.
  • Table S1. Pearson correlation analysis between the subchondral bone plate thickness and the articular cartilage thickness within the three main regions.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data of the figures.