Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Focal lesions in TBI participants.
  • Fig. S2. Individual data points as well as means and SDs for demographic and neuropsychological results in the healthy control group, disabled TBI subgroup, and good recovery TBI subgroup.
  • Fig. S3. Flortaucipir binding and focal lesions.
  • Fig. S4. Voxel-wise comparisons between subgroups in flortaucipir binding.
  • Fig. S5. Flortaucipir medial temporal lobe BPND in the healthy control, disabled TBI, and good recovery TBI groups.
  • Fig. S6. Relationships of CSF T-tau and P-tau and plasma T-tau concentrations with flortaucipir gray matter BPND, white matter BPND, and spatial extent in TBI and healthy controls.
  • Fig. S7. Relationships of CSF and plasma UCH-L1, NFL, GFAP, S100, and CSF Aβ42 with cerebral gray matter and white matter flortaucipir BPND in TBI and healthy controls.
  • Fig. S8. Gray matter density within areas of increased flortaucipir BPND in TBI.
  • Fig. S9. Flortaucipir right parietal cluster (TBI > control) BPND (z-score compared to healthy controls) and FA in white matter tracts in TBI.
  • Fig. S10. No difference in flortaucipir BPND (z-score compared to healthy controls) or spatial extent (number of voxels above threshold) in TBI when comparing individuals with at least one APOE ε4 allele and those not carrying an ε4 allele.
  • Fig. S11. Interactions between APOE genotype and each of time since injury, age, CSF T-tau, P-tau, Aβ42, NFL, GFAP, S100 concentrations, white matter and gray matter densities, and MMSE scores (longitudinal change and current) on flortaucipir BPND [z-score compared to controls and spatial extent (N voxels above threshold)] in TBI.
  • Fig. S12. Off-target flortaucipir binding in the striatum and choroid plexus compared to other cerebral areas in healthy controls and TBI.
  • Fig. S13. Flortaucipir reference region (cerebellar gray matter) time activity curves.
  • Table S1. Correlations between neuropsychological measures and average white matter tract FA in TBI.
  • Table S2. Correlations between flortaucipir right parietal cluster (TBI > control) BPND (z-score compared to healthy controls) and FA in white matter tracts in TBI participants.
  • Table S3. Correlations between clinical measures and each of flortaucipir right parietal cluster (TBI > control) BPND, whole cerebral cortex BPND (z-score compared to the healthy control group), white matter BPND (z-score compared to the healthy control group), and spatial extent (N of voxels with BPND z-score > 1.645 of healthy controls) in TBI participants.
  • References (6982)

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