Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Description of the TRUSPA imaging system next to the patient bed in the urology clinic.
  • Fig. S2. Schematics and images that describe the TRUSPA device, operating principle, and its data acquisition.
  • Fig. S3. Images of the CMUT array and ASIC.
  • Fig. S4. Simulated output pressure of a CMUT cell and experimental impedance measurements of a single CMUT element.
  • Fig. S5. Design and characterization of PDMS lens on the CMUT array.
  • Fig. S6. Time sequence used for simultaneous US and PAI of the TRUSPA device.
  • Fig. S7. Characterizing the US field of the TRUSPA device using simulations and experiments.
  • Fig. S8. Output pressure of the TRUSPA device, recorded by hydrophone in immersion, as a function of different DC and AC bias voltage settings.
  • Fig. S9. Characterization of TRUSPA system SNR as a function of depth and wavelength.
  • Fig. S10. Multiwavelength PA images of the mouse prostate tumor imaged with intravenous ICG.
  • Fig. S11. Multi-ROI time activity of ICG for the patient case presented in Fig. 7.
  • Fig. S12. Multiwavelength PA images of human prostate for the patient case presented in Fig. 7.
  • Fig. S13. Analysis of ICG activity during in vivo TRUSPA imaging of a human patient with PCa intravenously administered 75 mg of ICG at a concentration of 2.5 mg/ml.
  • Fig. S14. Analysis of ICG activity during in vivo TRUSPA imaging of a human patient with PCa intravenously administered 5 mg of ICG at a concentration of 2.5 mg/ml.
  • Table S1. 1D (linear) CMUT array parameters.
  • Table S2. Typical deep-tissue imaging parameters of the TRUSPA device.
  • Table S3. Intravenous ICG dose given to 10 human subjects at a concentration of 2.5 mg/ml.
  • Legend for movie S1

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). In vivo TRUSPA imaging of human prostate in clinic (without administering contrast agent).