Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Lysozyme contributes to pain sensitivity in PSL rats.
  • Fig. S2. Lysozyme also induces pain in female rats.
  • Fig. S3. Chitobiose treatment did not affect neuronal firing properties.
  • Fig. S4. Lysozyme interacts specifically with annexin A2.
  • Fig. S5. Lysozyme treatment increases NFκB p65 expression and its nuclear localization in neuronal cell lines.
  • Fig. S6. Lysozyme specifically regulates NFκB p65 through annexin A2 in SH-SY5Y human neuronal cells.
  • Fig. S7. Lysozyme activates both Aδ- and C-fiber nociceptors.
  • Fig. S8. Micrograph showing different stages of human primary neuronal cell culture.
  • Fig. S9. Schematic diagram representing the proposed mechanism of lysozyme action on DRG neurons.
  • Table S1. Clinical details of human patients.
  • Table S2. List of reagents.
  • References (5362)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S3. Raw data (provided as separate Excel file).
  • Movie S1 (.mp4 format). Activity of a scrambled siRNA–treated Sprague Dawley rat model of neuropathic pain.
  • Movie S2 (.mp4 format). Activity of a lysozyme-siRNA–treated Sprague Dawley rat model of neuropathic pain.
  • Movie S3 (.mp4 format). Activity of a sham-operated Sprague Dawley rat.
  • Movie S4 (.mp4 format). Activity of aCSF-injected Sprague Dawley rat.
  • Movie S5 (.mp4 format). Activity of lysozyme-injected Sprague Dawley rat.
  • Movie S6 (.mp4 format). Activity of lysozyme-injected female Sprague Dawley rat.