Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Fabrication of the snake fang–inspired MN patch.
  • Fig. S2. Optimization of UV exposure conditions for the fabrication of MNs with robust structures and sharp tips.
  • Fig. S3. Penetration of MG-MNs into the human and porcine skin.
  • Fig. S4. Fabrication of MG-MNs.
  • Fig. S5. Automated skin penetration test.
  • Fig. S6. Schematic of the spectral domain OCT system.
  • Fig. S7. Schematic of the OCM system.
  • Fig. S8. Mechanical property test of MN arrays.
  • Legends for movies S1 to S3

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Primary data.
  • Movie S1 (.avi format). 3D confocal reconstruction of the hexa-grooved MN.
  • Movie S2 (.avi format). 3D reconstruction showing the penetration of the hexa-grooved MN (red) loaded with FITC-BSA (green) into the dorsal skin of mice across the SC (blue).
  • Movie S3 (.avi format). Simulation of liquid drug delivery in a single groove of MG-MN.