Supplementary Materials

The PDF file includes:

  • Fig. S1. AAV1-delivered rh-eCD4-IgI39N affords complete protection from high-dose challenges with SHIV-AD8.
  • Fig. S2. Functional characterization of rh-eCD4-IgI39N expressed from an AAV gene cassette.
  • Fig. S3. In vivo rh-eCD4-IgI39N concentrations plotted against number of SIVmac239 challenges until infection.
  • Fig. S4. Protection from SIVmac239 is not due to a xenogenic response to the AAV1 vector.
  • Fig. S5. Alignment of full-length SIVmac239 gp160 sequences cloned from infected macaques.
  • Fig. S6. Sensograms of SIVmac239 gp120 variants binding rh-CD4-Ig and rh-CD4-IgI39N.

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Other Supplementary Material for this manuscript includes the following: