Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. ΔRh110 RhCMV/SIV vector design and supertope amino acid sequences.
  • Fig. S2. Comparison of the amino acid sequence of SIVmac239 versus SIVsmE660/smE543 vaccine inserts.
  • Fig. S3. Analysis of SIV Env–specific Ab responses after vaccination and after acquisition of SIV infection.
  • Fig. S4. Acquisition of SIV infection by groups 1, 2, and 3 RMs with repeated, limiting-dose IVag SIVmac239 challenge.
  • Fig. S5. Immune correlates analysis.
  • Fig. S6. Analysis of SIV Gag– and SIV Pol–specific CD4+ and CD8+ T cell responses after SIV infection.
  • Fig. S7. Analysis of circulating monocyte activation after SIV infection.
  • Fig. S8. Analysis of plasma viral load and SIV Vif–, SIV Gag–, and SIV Pol–specific CD4+ and CD8+ T cell responses in vaccine-protected, necropsied RMs from groups 1 and 2.
  • Fig. S9. Analysis of SIV Gag– and SIV Pol–specific CD4+ and CD8+ T cell responses in vaccine-protected and subsequently rechallenged RMs from groups 1, 2, and 4.
  • References (4046)

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Other Supplementary Material for this manuscript includes the following: