Supplementary Materials

The PDF file includes:

  • Fig. S1. TGFβ stimulation induced pSMAD2 nuclear localization, Alk5 inhibition prevented EMT, and cathepsin B and L inhibition did not alter EMT.
  • Fig. S2. Broad-spectrum calpain inhibition induced mesenchymal-to-epithelial transition in NMuMG cells.
  • Fig. S3. Expression of dimeric calpain message in mouse tissue and expression of EMT transcription factors in NMuMG cells.
  • Fig. S4. Calpain inhibition suppressed mesenchymal transition in multiple cell types.
  • Fig. S5. TGFβ induced expression of CAPN9 protein with coordinated translation-dependent mRNA decay in NMuMG cells.
  • Fig. S6. Capn9−/− mice expressed stable Capn9 message that lacks exon 3.
  • Fig. S7. Bleomycin induced an equal inflammatory response in wild-type and Capn9−/− animals.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.