Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Anti-QAM, anti-suxamethonium, anti-atracurium, and anti-rocuronium IgE and IgG ImmunoCAP.
  • Fig. S2. NMBA-dependent analyses of FcR expression.
  • Fig. S3. Complement pathway CH50, C3, and C4 during AHR versus V2.
  • Fig. S4. NMBA-dependent analyses of neutrophil CD11b and CD18 expression and circulating NETs.
  • Fig. S5. Effect of resuscitation fluids and drugs used during AHR on neutrophil activation.
  • Fig. S6. IgG markers in patients with strong evidence of IgE pathway.
  • Fig. S7. MST analyses of rocuronium and suxamethonium protein partners.
  • Fig. S8. Characterization of patient-derived anti-rocuronium IgG.
  • Fig. S9. Human neutrophil activation by soluble NMBA–anti-NMBA IgG ICs.
  • Table S1. Individual values of QAM IgE (kilounits per liter) and QAM IgG (micrograms per milliliter) for case-control pairs.
  • Table S2. Tryptase and histamine measurements.
  • Table S3. Flow cytometry antibodies.
  • Table S4. Nuclear magnetic resonance data of carboxylated rocuronium in D2O.
  • Reference (80)

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Other Supplementary Material for this manuscript includes the following: