Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. REGN4018 lacks antibody-dependent cell-mediated cytotoxicity and complement dependent cytotoxicity functions.
  • Fig. S2. PD-1 and CD25 are up-regulated in response to both REGN4018 and anti-CD3/anti-CD28 stimulation.
  • Fig. S3. REGN4018 binds CA-125 to a much lower degree than anti-MUC16 clone 3A5.
  • Fig. S4. REGN4018 did not induce any weight loss in animals with detectable drug concentrations.
  • Fig. S5. MUC16 expression is maintained in vivo after REGN4018 treatment.
  • Fig. S6. BLI at baseline correlates with complete tumor clearance.
  • Fig. S7. Human T cells are maintained after transfer of human PBMCs and can respond to anti-CD3 or REGN4018.
  • Fig. S8. Antitumor efficacy and cytokine induction by REGN4018 require T cells and MUC16-expressing OVCAR-3/Luc cells.
  • Fig. S9. PD-1 blockade enhances efficacy of suboptimal REGN4018 in the xenogenic OVCAR-3 model.
  • Fig. S10. MUC16 expression in the lung from cynomolgus monkey.
  • References (4246)

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