Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Expression of the miR-181 family affects adipocyte function and body composition.
  • Fig. S2. miR-181–deficient mice have increased energy expenditure during HFD feeding.
  • Fig. S3. miR-181–deficient mice have increased energy expenditure at baseline.
  • Fig. S4. miR-181–deficient mice have increased energy expenditure in the context of a cold challenge.
  • Fig. S5. Expression of miR-181 regulates glucose homeostasis and WAT inflammatory status during obesity.
  • Fig. S6. Conditional deletion of the miR-181 family in T cells, Tregs, macrophages, or hepatocytes does not affect glucose homeostasis or body composition.
  • Fig. S7. Inflammatory cytokines and LPS are not regulators of miR-181 expression.
  • Fig. S8. Indole and its hepatic metabolic by-product, indoxyl sulfate, inhibit the expression of miR-181 and adipocyte function.
  • Fig. S9. Working model: The gut microbiota regulates progression of obesity and WAT inflammation through a miRNA family expressed in white adipocytes.
  • References (4650)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Raw data from figures.