Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Manhattan plot of both RVVC cohorts.
  • Fig. S2. Genomic region of SIGLEC15 and surrounding genetic variants in linkage disequilibrium with rs2919643.
  • Fig. S3. Validation of rs2919643 in an independent cohort.
  • Fig. S4. Genotype stratification after stimulation with S. aureus.
  • Fig. S5. SIGLEC15 expression in different cell types.
  • Fig. S6. Binding of SIGLEC15 to different Candida strains.
  • Fig. S7. Flow cytometry of mouse cells after Candida stimulation.
  • Fig. S8. Silencing efficiency in mouse siRNA experiments.
  • Table S1. RVVC-associated cSNPs with concordant effects in both cohorts.
  • Table S2. GO characterization of genes that have cSNPs associated with RVVC in both cohorts.
  • Table S3. FRVs.
  • Legend for table S4
  • Table S5. GO characterization of genes associated with both RVVC risk and QTL.
  • Table S6. Proxies for rs2919643 in SIGLEC15 and their degree of linkage disequilibrium.

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Other Supplementary Material for this manuscript includes the following:

  • Table S4 (Microsoft Excel format). Rare variants in both cohorts after multiple testing correction.