Supplementary Materials

The PDF file includes:

• Materials and Methods
• Fig. S1. Internalization of insoluble fibrils leads to αSyn accumulation and proteome alterations.
• Fig. S2. An SCF E3 ubiquitin ligase targets internalized αSyn for ubiquitination and degradation.
• Fig. S3. An SCF inhibits the prion-like properties of extracellular αSyn.
• Fig. S4. SCF^FBXL5 inhibits LB-like pathology induced by extracellular αSyn fibrils.
• Table S4. Gene ontology enrichment analysis according to the Panther database.
• Table S5. KEEG pathway enrichment analysis according to the STRING database.

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). Label-free quantification of proteins from SH-SY5Y cells treated with the αSyn species.
• Table S2 (Microsoft Excel format). Label-free quantification of peptides from SH-SY5Y cells treated with the αSyn species.
• Table S3 (Microsoft Excel format). DEPs from SH-SY5Y cells treated with the αSyn species.
• Data file S1. Source data (Excel file).