Supplementary Materials
The PDF file includes:
- Materials and Methods
- Fig. S1. Internalization of insoluble fibrils leads to αSyn accumulation and proteome alterations.
- Fig. S2. An SCF E3 ubiquitin ligase targets internalized αSyn for ubiquitination and degradation.
- Fig. S3. An SCF inhibits the prion-like properties of extracellular αSyn.
- Fig. S4. SCFFBXL5 inhibits LB-like pathology induced by extracellular αSyn fibrils.
- Table S4. Gene ontology enrichment analysis according to the Panther database.
- Table S5. KEEG pathway enrichment analysis according to the STRING database.
Other Supplementary Material for this manuscript includes the following:
- Table S1 (Microsoft Excel format). Label-free quantification of proteins from SH-SY5Y cells treated with the αSyn species.
- Table S2 (Microsoft Excel format). Label-free quantification of peptides from SH-SY5Y cells treated with the αSyn species.
- Table S3 (Microsoft Excel format). DEPs from SH-SY5Y cells treated with the αSyn species.
- Data file S1. Source data (Excel file).