Supplementary Materials

The PDF file includes:

• Materials and Methods
• Fig. S1. Fractionation and sorting of liver cell subpopulations.
• Fig. S2. LV biodistribution within the liver cell subpopulations.
• Fig. S3. Generation of CD47-negative cells.
• Fig. S4. Generation of CD47-overexpressing cells.
• Fig. S5. Cytokine and chemokine response to LV, CD47hi LV, or CD47-free LV administration in NOD mice.
• Fig. S6. Cytokine and chemokine response to LV or CD47hi LV administration in NHPs.
• Fig. S7. LV gene therapy in NHPs.
• Fig. S8. IS analysis in CD47hi LV– or LV-treated NHP spleen.
• Table S1. Large-scale LV batches used in NHP study.
• Table S2. Clinical biochemistry, hematology, and hemostasis of vehicle NHP.
• Table S3. Clinical biochemistry, hematology, and hemostasis of LV1.
• Table S4. Clinical biochemistry, hematology, and hemostasis of LV2.
• Table S5. Clinical biochemistry, hematology, and hemostasis of LV3.
• Table S6. Clinical biochemistry, hematology, and hemostasis of CD47hi LV1.
• Table S7. Clinical biochemistry, hematology, and hemostasis of CD47hi LV2.
• Table S8. Clinical biochemistry, hematology, and hemostasis of CD47hi LV3.
• Table S9. LV IS in NHPs.
• Table S10. LV IS in cancer genes.
• Table S11. LV CIS.
• Legend for movie S1
• References (46–53)

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.mov format). IV2PM of LVs, CD47hi LVs, or CD47-free LVs upon administration.