Supplementary Materials
The PDF file includes:
- Materials and Methods
- Fig. S1. Fractionation and sorting of liver cell subpopulations.
- Fig. S2. LV biodistribution within the liver cell subpopulations.
- Fig. S3. Generation of CD47-negative cells.
- Fig. S4. Generation of CD47-overexpressing cells.
- Fig. S5. Cytokine and chemokine response to LV, CD47hi LV, or CD47-free LV administration in NOD mice.
- Fig. S6. Cytokine and chemokine response to LV or CD47hi LV administration in NHPs.
- Fig. S7. LV gene therapy in NHPs.
- Fig. S8. IS analysis in CD47hi LV– or LV-treated NHP spleen.
- Table S1. Large-scale LV batches used in NHP study.
- Table S2. Clinical biochemistry, hematology, and hemostasis of vehicle NHP.
- Table S3. Clinical biochemistry, hematology, and hemostasis of LV1.
- Table S4. Clinical biochemistry, hematology, and hemostasis of LV2.
- Table S5. Clinical biochemistry, hematology, and hemostasis of LV3.
- Table S6. Clinical biochemistry, hematology, and hemostasis of CD47hi LV1.
- Table S7. Clinical biochemistry, hematology, and hemostasis of CD47hi LV2.
- Table S8. Clinical biochemistry, hematology, and hemostasis of CD47hi LV3.
- Table S9. LV IS in NHPs.
- Table S10. LV IS in cancer genes.
- Table S11. LV CIS.
- Legend for movie S1
- References (46–53)
Other Supplementary Material for this manuscript includes the following:
- Movie S1 (.mov format). IV2PM of LVs, CD47hi LVs, or CD47-free LVs upon administration.