Supplementary Materials

The PDF file includes:

  • Fig. S1. Representative histograms of flow cytometry analysis for antigenic phenotype of CPCs and CDCs at P3.
  • Fig. S2. Comparative analysis of senescence and transwell migration potential of CPCs and CDCs.
  • Fig. S3. Growth potential of CPCs and CDCs in CDC and CPC growth medium.
  • Fig. S4. Effect of increasing number (percentage) of c-kit+ cells in CDCs on their migration potential.
  • Fig. S5. Quantification and functionality of exosomes derived from CPCs and CDCs.
  • Fig. S6. Complete immunoblots related to Fig. 3F.
  • Fig. S7. Schematic of donor human exosome purification and identification from recipient rat serum after cellular transplantation.
  • Fig. S8. Complete immunoblots related to Fig. 3J.
  • Fig. S9. Computational modeling of exosome miRNA cargo.
  • Fig. S10. PLSR analysis of gene array.
  • Fig. S11. miRNAs predicted to improve cardiac function by enhancing angiogenesis.
  • Table S1. Source of heart biopsies for CPC and CDC generation.
  • Table S2. Top 50 mRNA changes (CPC compared to CDC).
  • Table S3. Exosome miRNA VIP.
  • Table S4. miRNAs with their roles in cardioprotective processes.
  • Table S5. List of canonical signaling pathways affected by VIP miRNAs.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.