Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Alignment and similarity of Env amino acid sequences of WEEV, EEEV, and VEEV.
  • Fig. S2. WEEV, EEEV, and VEEV Env-pseudotyped lentiviral reporters have similar luciferase activity.
  • Fig. S3. Transmission electron microscopy and cryogenic electron microscopy images of monovalent VLPs.
  • Fig. S4. Monovalent VLP vaccine conferred complete protection against homologous virus challenge in cynomolgus macaques.
  • Fig. S5. The trivalent VLP vaccine protected against virus challenge and eliminated clinically significant neuropathology and persistent viral infection in NHPs.
  • Table S1. Observation of clinical signs and viremia after WEEV challenge in mice.

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Other Supplementary Material for this manuscript includes the following: