Supplementary Materials

The PDF file includes:

• Materials and Methods
• Fig. S1. Structural characterization of CD40L-Tn3 molecule and interactions.
• Fig. S2. Mouse surrogate Tn3 shows potent neutralizing activity in vivo in response to immunization.
• Fig. S3. Study design for phase 1a study to evaluate safety of VIB4920.
• Fig. S4. Phase 1b study design to evaluate VIB4920 in patients with RA.
• Fig. S5. Dose-dependent reduction in DAS28-CRP and RF autoantibodies in RA in response to VIB4920.
• Fig. S6. Impact of VIB4920 on tender/swollen joint counts and CRP in phase 1b study in patients with RA.
• Table S1. Fusion with serum albumin greatly improves half-life of Tn3 molecule.
• Table S2. VIB4920 demonstrates a good safety profile in healthy volunteers.
• Table S3. VIB4920 demonstrates an acceptable safety profile in patients with RA.
• Table S4. DAS28 categories at day 85.

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Primary data.