Supplementary Materials

The PDF file includes:

  • Fig. S1. Calculated stress fields across a circular scaffold with homogeneous structure at 10% displacement of the loading platen.
  • Fig. S2. Representative images of regenerated tissues at 6 and 12 weeks postoperatively.
  • Fig. S3. Representative H&E-stained images of the interfaces between the implant and regenerated tissues and synovium in the double-stimuli group and control group.
  • Fig. S4. Semiquantitative analysis of collagen distribution by immunohistochemistry.
  • Fig. S5. Biomechanical properties of the regenerated meniscus at 6 and 12 weeks postoperatively.
  • Fig. S6. Gross and microscopic observations of joints at 6 and 12 weeks postoperatively.
  • Fig. S7. Dynamic loading and biomechanical properties.
  • Fig. S8. Representative images of positive and negative controls using tendon (COL-1) and articular cartilage (COL-2) samples from rabbits.
  • Fig. S9. Schematic diagram showing implantation of an engineered meniscus.
  • Fig. S10. Samples for tensile and compressive testing.
  • Table S1. Statistical significance for comparisons between the groups in Fig. 3 (A to C).
  • Table S2. Statistical significance for comparisons between the groups in Fig. 3D.
  • Table S3. Gross evaluation of meniscus implant scores.
  • Table S4. Statistical significance for comparisons between the groups in fig. S4.
  • Table S5. Histological features of implants.
  • Table S6. Statistical significance for comparisons between the groups in Fig. 5A.
  • Table S7. Statistical significance for comparisons between the groups in Fig. 5F and fig. S5.
  • Table S8. Statistical significance for comparisons between the groups in Fig. 5B.
  • Table S9. Statistical significance for comparisons between the groups in Fig. 5C.
  • Table S10. Statistical significance for comparisons between the groups in Fig. 5D.
  • Table S11. Statistical significance for comparisons between the groups in Fig. 5E.
  • Table S12. Statistical significance for comparisons between the groups in Fig. 5G.
  • Table S13. Statistical significance for comparisons between the groups in Fig. 5H.
  • Table S14. Statistical significance for comparisons between the groups in Fig. 5I.
  • Table S15. Statistical significance for comparisons between the groups in Fig. 5J.
  • Table S16. Primer sequences used for RT-PCR.
  • Table S17. Statistical significance for synergism between the biochemical and biomechanical stimuli.

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Other Supplementary Material for this manuscript includes the following: