Supplementary Materials

The PDF file includes:

• Fig. S1. Mucin flakes in CF.
• Fig. S2. Molecular microbiology in CF samples.
• Fig. S3. CF microbiology and antibiotic use.
• Fig. S4. Microrheologic effects of treatment.
• Fig. S5. P2062.
• Fig. S6. Disease pathogenesis in normal and early CF lung.
• Table S1. Diagnoses in non-CF disease control populations.
• Table S2. Bacterial infection by conventional culture in AREST CF and non-CF disease control populations as a function of bacterial density.
• Table S3. Multivariate analyses for BALF mucin parameters.
• Table S4. Correlation of mucins, MUC5B and MUC5AC to markers of inflammation and metabolomic markers of airway environment in CF BALF.
• Table S5. Multivariate analyses of mucins versus BALF metabolomic and inflammatory markers.
• Table S6. BALF markers in CF-NSD versus non-CF controls.
• Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

• Data file S1. Raw data (provided as separate Excel file).