Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Scheme of in vivo molecular MRI of renal fibrosis in three independent mouse models of renal fibrosis.
  • Fig. S2. Confirmation of increased elastin expression in renal fibrosis.
  • Fig. S3. Elastin expression in murine models of renal fibrosis.
  • Fig. S4. Identification of interstitial (myo-)fibroblasts as elastin-producing cells in fibrotic kidneys.
  • Fig. S5. Resident fibroblasts express elastin.
  • Fig. S6. Elastin expression in CKD patients.
  • Fig. S7. Staining validation by means of nonspecific secondary antibody and buffer control.
  • Fig. S8. Feasibility assessment of different MRI sequences and measurement times.
  • Fig. S9. Elastin imaging detects fibrosis in adenine nephropathy.
  • Fig. S10. Elastin imaging detects renal fibrosis in I/R.
  • Fig. S11. Elastin imaging detects renal fibrosis in UUO.
  • Fig. S12. Molecular MRI captures therapy effects in renal fibrosis.
  • Fig. S13. Molecular MRI analysis of renal fibrosis versus routine measurement of kidney function.
  • Fig. S14. Overall study and experimental design.
  • Table S1. Collection of patient fibrotic kidney samples reflecting different kidney diseases.
  • Table S2. IgA nephropathy patient cohort.
  • Table S3. List of primers used for qRT-PCR.
  • References (3840)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Individual subject-level data.