Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Physical parameters of the GRS as the drug weight increases.
  • Fig. S2. Serial radiographs of the GRS over 1 month in a swine model.
  • Fig. S3. Effect of the GRS on the weight and stomach tissue of swine.
  • Fig. S4. Hall effect sensor acid stability and retrieval using an in vitro stomach model.
  • Fig. S5. In vivo formulations and their corresponding 4-week in vitro drug release profiles of doxycycline hyclate–silicone pills of the 10 g GRS.
  • Fig. S6. In vivo release of rifampicin from the GRS in a swine model.
  • Fig. S7. Field questionnaire results at TB clinics in New Delhi, India.
  • Fig. S8. Field questionnaire results on NG tube deployment at TB clinics in New Delhi, India.
  • Table S1. Demographics of 111 TB health care providers who responded to the questionnaire study across TB clinics in New Delhi, India.
  • Table S2. Demographics of 300 patients with TB who responded to the questionnaire study across TB clinics in New Delhi, India.
  • Table S3. Modeled impact of TB treatment interruptions on health and economic costs in New Delhi, India annually.
  • Legend for table S4
  • Legends for data files S1 to S3
  • References (6068)

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Other Supplementary Material for this manuscript includes the following:

  • Table S4. Individual subject-level data for Figs. 2 (B to G) and 3 (C and D) and figs. S3A, S4A, S5B, S6, S7 (B and C), S7 (E and F), and S8 (Excel format).
  • Data file S1 (.STL format). In vitro design of 3D stomach model.
  • Data file S2 (.pdf format). Field questionnaire study to inform mode of administration.
  • Data file S3 (.xlsx format). Sensitivity analysis of health and economic model.