Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Coagulation pathway in IBD.
  • Fig. S2. SERPINE1 links myeloid inflammation and epithelial clusters and is enriched in IBD.
  • Fig. S3. SERPINE1 correlation cluster of genes dominated by ECM and cytokine pathways.
  • Fig. S4. PAI-1 increases severity of colonic tissue damage.
  • Fig. S5. IL-17A drives expression of Plat in colon epithelial cells.
  • Fig. S6. Plat/tPA protects against colitis and mucosal damage.
  • Fig. S7. A small-molecule PAI-1 inhibitor reduces severity of colitis in a tPA-dependent manner.
  • Fig. S8. TGF-β is partly responsible for tPA-mediated protection in colonic inflammation.
  • Fig. S9. SERPINE1 distinguishes between active and inactive disease and is elevated in anti–TNF-α nonresponders.
  • Reference (79)

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Cohorts analyzed.
  • Table S2 (Microsoft Excel format). Overrepresentation analysis in pathway tools.
  • Table S3 (Microsoft Excel format). Description of CERTIFI cohort used to construct the Bayesian network.
  • Table S4 (Microsoft Excel format). SERPINE1 correlation cluster set of genes determined by r2 global linear regression.
  • Table S5 (Microsoft Excel format). Genes regulated in primary colon epithelial cells by recombinant IL-17A treatment.
  • Table S6 (Microsoft Excel format). Genes that were differentially expressed (P < 0.05, twofold change) between responders and nonresponders to infliximab in biopsies taken before biologic therapy.
  • Data file S1 (Microsoft Excel format). Primary data.