Supplementary Materials

This PDF file includes:

• Materials and Methods
• Fig. S1. Significant DC differences between ASD and TD observed in the EU-AIMS LEAP dataset with and without control for motion in the group comparisons.
• Fig. S2. Connectivity indices computed based on the identified DC alterations.
• Fig. S3. Correlations between the initial DC findings and derived connectivity indices showing the largest effect sizes for differentiation between ASD and TD.
• Fig. S4. Plots of comorbidity status versus DC and hyper- and hypoconnectivity indices from ABIDE II cohort.
• Table S1. Mean motion in ASD and TD.
• Table S2. Results of analyses of variance testing for age category–by–diagnosis and sex-by-diagnosis interactions on the hyper- and hypoconnectivity indices.
• Table S3. Effects of medication on functional connectivity measures.
• Table S4. Contingency table of psychiatric comorbidity versus current medication status in ASD from ABIDE II.
• Table S5. Outcomes of EU-AIMS LEAP GLM analysis using ASD indices to predict clinical scores.
• Table S6. Age characteristics of the ADI and VABS subpopulations used for correlation with clinical scales.
• Table S7. Volumetric comparisons between ASD and TD in the EU-AIMS LEAP cohort.
• Table S8. Associations between structural and functional connectivity measures in the EU-AIMS LEAP cohort.
• Table S9. Additional clinical characteristics of the EU-AIMS LEAP population.
• Table S10. Additional clinical characteristics of the ABIDE I population.
• Table S11. Additional clinical characteristics of the ABIDE II population.
• Table S12. Summary of scanning parameters for each participating site in the EU-AIMS LEAP consortium.
• Table S13. Summary of scanning parameters for each participating site in the ABIDE I cohort.
• Table S14. Summary of scanning parameters for each participating site in the ABIDE II cohort.
• Table S15. Summary of scanning parameters used in the InFoR cohort.
• References (60, 61)

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