Supplementary Materials

The PDF file includes:

  • Materials and Methods
  • Fig. S1. Lesional skin has similar baseline TEWL in AD FA+ and AD FA− groups.
  • Fig. S2. Pruritus correlates with TEWL AUC in AD FA+ but not AD FA−.
  • Fig. S3. Lamellar bilayer structural integrity is abnormal in the skin of AD FA+.
  • Fig. S4. Shannon diversity index.
  • Fig. S5. Staphylococcus and Micrococcus species are more abundant on nonlesional skin of AD FA+ versus NA.
  • Fig. S6. Relative abundance of various bacterial genera are similar in AD lesional skin, regardless of FA.
  • Fig. S7. S. aureus is more abundant in nonlesional skin of AD FA+ than NA skin but similar to AD FA−.
  • Fig. S8. Skin lesions of AD FA+ and AD FA− have similar abundance of the Staphylococcus species.
  • Fig. S9. SPLOM showing all bivariate relationships between the variables in the network diagram (Fig. 7A).
  • Fig. S10. Type 2 immune response gene expression in the nonlesional skin of AD FA+, AD FA−, and NA groups.
  • Table S1. Characteristics of study participants by diagnostic group.
  • Table S2. Comparisons between groups for TEWL.
  • Table S3. Correlations between food-specific IgE and skin test results with TEWL.
  • Table S4. Comparisons between groups for FLG breakdown products.
  • Table S5. Comparisons between groups for FLG breakdown products with the corresponding TEWL.
  • Table S6. Comparisons between groups total EOS CER, total C18 NS CER, and NS CER.
  • Table S7. Correlations between groups for total EOS CER, total C18 NS CER, and NS CER with the corresponding TEWL.
  • Table S8. Comparisons between groups for keratin expression in nonlesional skin.
  • Table S9. Correlations between keratin expression in nonlesional skin and TEWL.
  • Table S10. Genes (n = 288) associated with the AD FA+, AD FA−, and NA groups.
  • Table S11. Top 10 ingenuity canonical pathways.
  • References (6773)

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Primary data.
  • Data file S2 (Microsoft Excel format). Data for the skin microbiome.
  • Data file S3 (Microsoft Excel format). Data for the skin transcriptome.