Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Generation of mIDH1 mouse glioma model using the SB transposon system.
  • Fig. S2. Characterization of tumor NS generated from wt-IDH1 and mIDH1 mouse brain tumors and human glioma.
  • Fig. S3. Functional enrichment of DE genes in mIDH1-NS versus wt-IDH1–NS.
  • Fig. S4. Tumor cell differentiation phenotype in mIDH1 glioma.
  • Fig. S5. TICs in wt-IDH1 and mIDH1 glioma cells.
  • Fig. S6. In vivo cell cycle analysis on wt-IDH1 and mIDH1 tumors.
  • Fig. S7. Analysis of histone modifications in mIDH1-NS.
  • Fig. S8. DE genes in mIDH1-NS determined by RNA-seq analysis.
  • Fig. S9. Pathway enrichment map of differential gene expression in mIDH1 versus wt-IDH1 mouse NS.
  • Fig. S10. Analysis of DNA repair efficiency and DDR activity in wt-IDH1 and mIDH1 glioma.
  • Fig. S11. In vitro radioresistance analysis in wt-IDH1 and mIDH1 glioma cells.
  • Fig. S12. Clonogenic assay performed on wt-IDH1 and mIDH1 mouse and human glioma cells.
  • Fig. S13. Chromatin compaction in wt-IDH1 and mIDH1 cells.
  • Fig. S14. Heat map showing gene expression for DNA repair pathways in mIDH1-NT and mIDH1-R (20 Gy).
  • Fig. S15. Impact of DDR activity on in vitro radio response in mIDH1 glioma cells.
  • Fig. S16. Diagram of epigenetic reprograming elicited by mIDH1 on DDR pathway up-regulation, survival, and response to radiotherapy in glioma.
  • Table S1. Antibodies.
  • Table S2. Oligonucleotides.
  • References (4051)

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